Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A2A receptor as potential antitumor agents
Flavia Varano, Daniela Catarzi, Fabrizio Vincenzi, Silvia Pasquini, Julie Pelletier, Juliana Lopes Rangel Fietto, Nicolly Espíndola Gelsleichter, Marine Sarlandie, Audrey Guilbaud, Jean Sévigny, Katia Varani, Vittoria Colotta
Topics & Concepts
ChemistryAdenosineAdenosine receptorPyrimidineStereochemistryReceptorEnzymeG protein-coupled receptorPotencyAdenosine A2A receptorPharmacologyBiochemistryCombinatorial chemistryIn vitroAgonistMedicineAdenosine and Purinergic SignalingSynthesis and Biological EvaluationPharmacological Receptor Mechanisms and Effects