Inflammatory markers in systemic immune-inflammatory index and inflammatory response index to predict early pregnancy loss
Nihal Çallıoğlu, Derya KANZA GÜL, İlke Özer Arslan, Ipek Emine Geyikoglu, Ergül Demirçivi Bör
Abstract
<h3>Objectives:</h3> To uncover the predictive value of systemic immune-inflammatory index (SII) and systemic inflammatory response index (SIRI) on early pregnancy loss. <h3>Methods:</h3> A total of 535 individuals were enrolled in this retrospective analysis. The early pregnancy losses (EPL) group included patients between 18-35 years old who experienced EPL. The control group comprised healthy pregnant women who gave birth at ≥37 weeks. <h3>Results:</h3> The EPL group had significantly lower plateletcrit (<i>p</i>=0.04), platelet distribution width (PDW, <i>p</i><0.0001), and RDW (<i>p</i><0.0001) and higher monocyte (<i>p</i><0.0001) and SIRI (<i>p</i><0.0001) values than the control group. The hemoglobin, white blood cells, platelet count, neutrophil count, lymphocyte count, mean platelet volume, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and SII values were not significantly different between the EPL and control groups (<i>p</i>>0.05). The cut-off value for the SIRI that offers the best sensitivity/specificity balance was 1.48 (sensitivity of 63%; specificity of 63%) in the receiver operating characteristics curve. Among the inflammatory parameters for predicting EPL, PDW had highest specificity (84%), and RDW had the highest sensitivity (80%). <h3>Conclusion:</h3> This study provides compelling evidence that various inflammatory pathways may significantly contribute to EPL pathogenesis. Moreover, our findings suggest that SIRI could be a more effective marker than NLR, PLR, MLR, and SII in predicting EPL in an ongoing pregnancy, thereby potentially revolutionizing early pregnancy loss diagnostics.