Litcius/Paper detail

Investigation of the internal structure and dynamics of gum cancer cells, tissues and tumors by 13C–NMR spectra of DNA/RNA of gum cancer cells as an essential structural tool for integrative studies of gum cancer cells development

Alireza Heidari, Ricardo Gobato

2020Dental Oral and Maxillofacial Research36 citationsDOIOpen Access PDF

Abstract

In the current paper, investigation of the internal structure and dynamics of gum cancer cells, tissues and tumors by 13C-NMR spectra of DNA/RNA of gum cancer cells as an essential structural tool for integrative studies of gum cancer cells development are studied. Internal structure and dynamics of gum cancer cells, tissues and tumors by 13C-NMR spectra of DNA/RNA of gum cancer cells as an essential structural tool for integrative studies of gum cancer cells development-based diagnostics and imaging offer many advantages over the routine clinical techniques non-invasiveness, tissue removing is not required, minimal sample processing, labeling is not required, no prior knowledge to target molecules (e.g. antibodies) is required, safety, non-ionizing electromagnetic field is used, no external dyes/ contrast agents are needed to produce human organs images. The method is faster and cheaper to perform, which will result in quicker patient diagnosis, fewer time delays, less pain, and trauma of patients, less cost to the hospital. Investigation of the internal structure and dynamics of gum cancer cells, tissues and tumors by 13C-NMR spectra of DNA/RNA of gum cancer cells as an essential structural tool for integrative studies of gum cancer cells development based methods with the sensitivity and specificity of over 90% for in vivo and ex vivo measurements might be applied to clinical practice with a positive economic impact due to reducing of false biopsy and risk of incomplete tumor resection.

Topics & Concepts

DNACancerDynamics (music)RNACarbon-13 NMRChemistryCancer researchBiochemistryBiologyStereochemistryGeneGeneticsPsychologyPedagogyBiopolymer Synthesis and ApplicationsTannin, Tannase and Anticancer ActivitiesCancer and biochemical research