The C <sub>2</sub> H <sub>2</sub> Transcription Factor SltA Contributes to Azole Resistance by Coregulating the Expression of the Drug Target Erg11A and the Drug Efflux Pump Mdr1 in Aspergillus fumigatus
Wenlong Du, Pengfei Zhai, Tingli Wang, Michael Bromley, Yuanwei Zhang, Ling Lü
Abstract
-mediated itraconazole resistance. Most importantly, deletion of SltA in laboratory-derived and clinical azole-resistant isolates significantly attenuates drug resistance. Collectively, we have identified a new function of the transcription factor SltA in regulating azole resistance by coordinately mediating the key azole target Erg11A and the drug efflux pump Mdr1, and targeting SltA may provide a potential strategy for intervention of clinical azole-resistant isolates to improve the efficiency of currently approved antifungal drugs.
Topics & Concepts
EffluxDrug resistanceDrugTranscription factorAzoleMultiple drug resistancePharmacologyChemistryBiologyGeneticsGeneMicrobiologyAntifungalAntifungal resistance and susceptibilityFungal Biology and ApplicationsSynthesis and Biological Evaluation