Design, synthesis and pharmacological evaluation of 2-arylurea-1,3,5-triazine derivative (XIN-9): A novel potent dual PI3K/mTOR inhibitor for cancer therapy
Xin Sun, Binliang Zhang, Leixuan Luo, Yang Yang, Bin He, Qian Zhang, Linxiao Wang, Shan Xu, Pengwu Zheng, Wufu Zhu
Topics & Concepts
PI3K/AKT/mTOR pathwayChemistryHeLaProtein kinase BApoptosisCell growthKinaseCell cyclePharmacologyCancer cellIn vitroCancer researchCancerBiochemistryBiologyMedicineInternal medicineSynthesis and Characterization of Heterocyclic CompoundsQuinazolinone synthesis and applicationsSynthesis and biological activity