Prevalence of hypervirulent and carbapenem-resistant <i>Klebsiella pneumoniae</i> under divergent evolutionary patterns
Dongxing Tian, Xiao Liu, Wenjie Chen, Ying Zhou, Dakang Hu, Weiwen Wang, Jinzuan Wu, Qing Mu, Xiaofei Jiang
Abstract
mutation reduced capsular synthesis and increased carbapenem resistance of the CR-hvKp strain. In summary, this study revealed that hv-CRKP strains were more suitable for survival in hospital settings than CR-hvKp strains and the widespread conjugative KPC-producing plasmids contributed to the emergence and prevalence of hv-CRKP strains.
Topics & Concepts
VirulencePlasmidKlebsiella pneumoniaeMicrobiologyBiologyAerobactinCarbapenemVirologyGeneEnterobacteriaceaeGeneticsEscherichia coliAntibioticsAntibiotic Resistance in BacteriaGenomics and Phylogenetic StudiesBacterial Genetics and Biotechnology