Novel copper-based and pH-sensitive nanomedicine for enhanced chemodynamic therapy
Li Wang, Zhicheng Zhang, Yawen Ding, Jinhui Wu, Yiqiao Hu, Ahu Yuan
Abstract
We utilized albumin as a reducing agent to establish novel copper-based and pH-sensitive nanocarrier CuNPs with abundant Cu+, which can encapsulate histone deacetylase (HDAC) inhibitor vorinostat to form uniform and stable nanomedicine V-CuNPs for synergistic chromatin remodelling and chemodynamic therapy.
Topics & Concepts
NanocarriersChemistryNanomedicineCopperChromatinBiophysicsCombinatorial chemistryNanotechnologyBiochemistryNanoparticleDrug deliveryMaterials scienceBiologyOrganic chemistryDNANanoparticle-Based Drug DeliveryNanocluster Synthesis and ApplicationsNanomaterials for catalytic reactions