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Artesunate reverses LPS tolerance by promoting ULK1-mediated autophagy through interference with the CaMKII-IP3R-CaMKKβ pathway

Xin Liu, Jiaqi Wu, Ning Wang, Lin Xia, Shijun Fan, Yongling Lu, Xiaoli Chen, Shenglan Shang, Yongjun Yang, Qianying Huang, Qian Chen, Hong Zhou, Jiang Zheng

2020International Immunopharmacology18 citationsDOI

Topics & Concepts

AutophagyArtesunateAMPKULK1PI3K/AKT/mTOR pathwayKinaseCell biologyProtein kinase APharmacologyPhosphorylationInnate immune systemChemistryBiologySignal transductionImmune systemImmunologyBiochemistryApoptosisMalariaPlasmodium falciparumAutophagy in Disease and TherapyCalcium signaling and nucleotide metabolismMosquito-borne diseases and control
Artesunate reverses LPS tolerance by promoting ULK1-mediated autophagy through interference with the CaMKII-IP3R-CaMKKβ pathway | Litcius