Lipids and lipoproteins in cardiovascular diseases: a classification
Shruti Bhargava, Sofía de la Puente-Secades, Leon J. Schurgers, Joachim Jankowski
Abstract
Lipids and lipoproteins, their metabolism, and their transport are essential contributing factors of cardiovascular disease (CVD) as they regulate plasma cholesterol concentration, enhancing cholesterol uptake by macrophages, leading to foam cell formation and ultimately resulting in plaque formation and inflammation. However, lipids and lipoproteins have cardioprotective functions as well, such as preventing oxidation of proatherogenic molecules and downregulating inflammatory proteins.
Topics & Concepts
MedicineAtherosclerotic cardiovascular diseaseInternal medicineCardiologyDiseaseLipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and LipoproteinsCancer, Lipids, and Metabolism