The gut microbiota mediates protective immunity against tuberculosis <i>via</i> modulation of lncRNA
Fang Yang, Yi Yang, Lingming Chen, Zhiyi Zhang, Linna Liu, Chunmin Zhang, Qiongdan Mai, Yiwei Chen, Zixu Chen, Tao Lin, Chen Liang, Huixin Guo, Lin Zhou, Hongbo Shen, Xinchun Chen, Lei Liu, Guoliang Zhang, Hong-Ying Liao, Lingchan Zeng, Gucheng Zeng
Abstract
infection. Mechanistically, lncRNA-CGB interacted with EZH2 and negatively regulated H3K27 tri-methylation (H3K27Me3) epigenetic programming, leading to enhanced IFN-γ expression. Thus, this work not only uncovered previously unrecognized importance of gut bacteria-lncRNA-EZH2-H3K27Me3 axis in conferring immune protection against TB but also identified a potential new paradigm to develop a microbiota-based treatment against TB and potentially other diseases.
Topics & Concepts
BiologyDysbiosisTuberculosisGut floraMycobacterium tuberculosisImmunityImmunologyBacteroides fragilisImmune systemMicrobiologyInnate immune systemMicrobiomeAntibioticsGeneticsMedicinePathologyMycobacterium research and diagnosisCancer-related molecular mechanisms researchGut microbiota and health