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Understanding T cell responses to COVID-19 is essential for informing public health strategies

Santosha A. Vardhana, Lance Baldo, William G. Morice, E. John Wherry

2022Science Immunology148 citationsDOIOpen Access PDF

Abstract

Durable T cell responses to SARS-CoV-2 antigens after infection or vaccination improve immune-mediated viral clearance. To date, population-based surveys of COVID-19 adaptive immunity have focused on testing for IgG antibodies that bind spike protein and/or neutralize the virus. Deployment of existing methods for measuring T cell immunity could provide a more complete profile of immune status, informing public health policies and interventions.

Topics & Concepts

Immune systemImmunityVaccinationImmunologyAcquired immune systemCoronavirus disease 2019 (COVID-19)AntibodyVirologyPopulationVirusPublic healthBiologyAntigenMedicineEnvironmental healthDiseaseInfectious disease (medical specialty)NursingPathologySARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studiesvaccines and immunoinformatics approaches
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