Neonatal B-Cell Levels and Infant Health in Newborns Potentially Exposed to Anti-CD20 Monoclonal Antibodies During Pregnancy or Lactation
Carolin Schwake, Julia Steinle, Sandra Thiel, Nina Timmesfeld, Sabrina Haben, Ilya Ayzenberg, Ralf Gold, Kerstin Hellwig
Abstract
OBJECTIVES: B-cell counts and possible adverse effects on infants of mothers exposed to anti-CD20 mAbs ≤6 months before/during pregnancy or lactation. METHODS: B-cell counts. Comparison with reference values was performed conservatively in a subgroup with maternal exposure ≤3 months before/during pregnancy. Additional outcomes included pregnancy results, severe infections, and lymphocyte counts. RESULTS: B-cell counts. DISCUSSION: B-cell depletion due to placental transfer, necessitating monitoring and postponing live vaccines.
Topics & Concepts
LactationPregnancyMonoclonal antibodyMonoclonalCD20MedicineAntibodyObstetricsImmunologyBiologyGeneticsDiabetes and associated disordersImmunodeficiency and Autoimmune DisordersT-cell and B-cell Immunology