Cancer-derived exosomal miR-138-5p modulates polarization of tumor-associated macrophages through inhibition of KDM6B
Jing Xun, Lingfang Du, Ruifang Gao, Long Shen, Dekun Wang, Lichun Kang, Chuan’ai Chen, Zhujun Zhang, Yuying Zhang, Shijing Yue, Shuxin Feng, Rong Xiang, Xue Mi, Xiaoyue Tan
Abstract
expression, inhibit M1 polarization, and stimulate M2 polarization. Therefore, exosomal miR-138-5p represents a promising prognostic marker and target for the treatment of breast cancer.
Topics & Concepts
Cancer researchMicrovesiclesMacrophage polarizationmicroRNAMetastasisDownregulation and upregulationCancer cellFlow cytometryTumor progressionCancerBiologyChemistryMacrophageMedicineImmunologyInternal medicineIn vitroBiochemistryGeneExtracellular vesicles in diseaseImmune cells in cancerMicroRNA in disease regulation