TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation
Linhan Wang, Jiqiang Li, Qingchen Wang, Man-Xi Ge, Jia Ji, Di Liu, Zhiyuan Wang, Yang Cao, Yaoyang Zhang, Zai-Rong Zhang
Topics & Concepts
Endoplasmic reticulumBiologyEndoplasmic-reticulum-associated protein degradationCell biologyTransmembrane proteinCytosolMembrane proteinTransmembrane domainUbiquitinAAA proteinsMembraneBiochemistryATPaseUnfolded protein responseEnzymeReceptorGeneEndoplasmic Reticulum Stress and DiseaseCellular transport and secretionRNA regulation and disease