Unprecedented polycyclic polyprenylated acylphloroglucinols with anti-Alzheimer's activity from St. John's wort
Yi Guo, Fang Huang, Weiguang Sun, Yuan Zhou, Chunmei Chen, Changxing Qi, Jing Yang, Xiao‐Nian Li, Zengwei Luo, Hucheng Zhu, Xiao‐Chuan Wang, Yonghui Zhang
Abstract
Ten PPAPs with unusual skeletons were isolated from H. perforatum . 6 represents the first multitargeted natural product that could activate PP2A and simultaneously inhibit BACE1, which highlights 6 as a promising lead compound in AD drug development.
Topics & Concepts
Natural productChemistryStereochemistryNatural Compound Pharmacology StudiesSynthesis of Organic CompoundsBioactive Compounds and Antitumor Agents