<i>Taraxacum mongolicum</i> Hand.-Mazz. derived extracellular vesicles alleviate mastitis <i>via</i> NLRP3 inflammasome and NF-κB/MAPK pathways
Yuan Sun, Ying Liu, Jinxian Li, Shan Huang, Yiyang Du, Danyang Chen, Min Yang, Yinghua Peng
Abstract
, TH-EVs alleviated histopathological damage, decreased myeloperoxidase activity, inhibited T lymphocyte activation, and reduced oxidative stress in mammary tissues. Mechanistically, TH-EVs inhibited the NLRP3 inflammasome, NF-κB and MAPK pathways. This study demonstrates that TH-EVs are a potent natural nanotherapeutic agent for mastitis, with potential for translational applications.
Topics & Concepts
InflammasomeMastitisBiologyMAPK/ERK pathwayMicrobiologyMedicineImmunologyInflammationSignal transductionCell biologyCancer-related molecular mechanisms researchMilk Quality and Mastitis in Dairy CowsCytokine Signaling Pathways and Interactions