Cu-Catalyzed Carbocyclization for General Synthesis of <i>N</i>-Containing Heterocyclics Enabled by BrCF<sub>2</sub>COOEt as a C1 Source
Xiaofang Song, Lijing Zhang, Xing‐Guo Zhang, Hai‐Yong Tu
Abstract
A practical and efficient copper-catalyzed carbocyclization of 2-functionalized anilines with ethyl bromodifluoroacetate has been developed. Ethyl bromodifluoroacetate is employed as the C1 source via quadruple cleavage in this transformation. This reaction can afford a variety of N -containing heterocyclics with satisfactory yields and excellent functional group compatibility.
Topics & Concepts
ChemistryCatalysisCombinatorial chemistryCompatibility (geochemistry)CopperOrganic chemistryChemical engineeringEngineeringFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms