Generation of host-directed and virus-specific antivirals using targeted protein degradation promoted by small molecules and viral RNA mimics
Nan Zhao, Jessica Ho, Fanye Meng, Simin Zheng, Andrew P. Kurland, Lu Tian, Martha Rea-Moreno, Xiangyang Song, Ji-Seon Seo, H. Ümit Kanıskan, Aartjan J.W. te Velthuis, Domenico Tortorella, Ya‐Wen Chen, Jeffrey R. Johnson, Jian Jin, Ivan Marazzi
Topics & Concepts
BiologyRNAUbiquitin ligaseRNA ligaseProtein degradationVirologyVirusOligonucleotideProteolysisUbiquitinViral proteinRNA virusSmall moleculeComputational biologyCell biologyDNABiochemistryEnzymeGeneProtein Degradation and InhibitorsPeptidase Inhibition and AnalysisUbiquitin and proteasome pathways