Yes-Associated Protein and Transcriptional Coactivator with PDZ-Binding Motif in Cardiovascular Diseases
Ruojun Li, Weiqiang Huang
Abstract
Yes-associated protein (YAP, also known as YAP1) and its paralogue TAZ (with a PDZ-binding motif) are transcriptional coactivators that switch between the cytoplasm and nucleus and regulate the organ size and tissue homeostasis. This review focuses on the research progress on YAP/TAZ signaling proteins in myocardial infarction, cardiac remodeling, hypertension and coronary heart disease, cardiomyopathy, and aortic disease. Based on preclinical studies on YAP/TAZ signaling proteins in cellular/animal models and clinical patients, the potential roles of YAP/TAZ proteins in some cardiovascular diseases (CVDs) are summarized.
Topics & Concepts
PDZ domainHippo signaling pathwayBiologyCell biologyCardiomyopathySignal transductionBioinformaticsCytoplasmTranscription factorMedicineCancer researchInternal medicineHeart failureGeneticsGeneHippo pathway signaling and YAP/TAZ