Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling
Sameer Nikhar, Ioannis Siokas, Lisa Schlicher, Seungheon Lee, Mads Gyrd‐Hansen, Alexei Degterev, Gregory D. Cuny
Topics & Concepts
ChemistrySignal transductionKinaseNOD2NodADMEProtein kinase ANOD1ReceptorPharmacologyBiochemistryIn vitroBiologyInnate immune systemGeneNF-κB Signaling PathwaysCytokine Signaling Pathways and InteractionsCell death mechanisms and regulation