In situ generation of hydroperoxide-rich-peptide-based nano-assemblies for self-amplified magnetic resonance imaging-guided synergistic tumor chemo/chemodynamic/ferroptotic therapy
Yin‐Jia Cheng, Qin Mo, Fangyu Zeng, Yuqing Wang, Muhai Liu, Yuting Li, Qiangyu Liu, Si‐Yong Qin, Wenlong Liu, Yihan Ma, Aiqing Zhang
Topics & Concepts
ChemistryDoxorubicinHydrogen peroxideSinglet oxygenReactive oxygen speciesGlutathioneCancer cellRadicalBiophysicsPeptideNanoparticleLipid peroxidationMoietyIntracellularMembraneCombinatorial chemistryPhotothermal therapyDrug deliveryHydroxyl radicalMagnetic nanoparticlesRational designCancer therapyNanocarriersNanocapsulesCancer treatmentLiposomeCell-penetrating peptidePhotodynamic therapyNanotechnologyBiochemistryCytotoxicityNanoplatforms for cancer theranosticsCancer, Hypoxia, and MetabolismNanoparticle-Based Drug Delivery