Pericyte-specific deletion of ninjurin-1 induces fragile vasa vasorum formation and enhances intimal hyperplasia of injured vasculature
Kiwamu Horiuchi, Kohei Kano, Akiho Minoshima, Taiki Hayasaka, Atsushi Yamauchi, Takamitsu Tatsukawa, Risa Matsuo, Yuri Yoshida, Yui Tomita, Maki Kabara, Naoki Nakagawa, Naofumi Takehara, Naoyuki Hasebe, Jun-ichi Kawabe
Abstract
Although abnormalities of adventitial vasa vasorum are associated with vascular remodeling such as atherosclerosis, the mechanisms of vasa vasorum malformation and its role in vascular remodeling have not been fully clarified. The present study provides a line of novel evidence that ninjurin-1 contributes to adventitial microvascular maturation during vascular injury and regulates vascular remodeling.
Topics & Concepts
Vasa vasorumPericyteIntimal hyperplasiaCell biologyAnatomyPathologyMedicineBiologySmooth muscleInternal medicineEndothelial stem cellIn vitroBiochemistryRetinal Diseases and TreatmentsIntracranial Aneurysms: Treatment and ComplicationsProtease and Inhibitor Mechanisms