Palladium-catalyzed allylic alkylation dearomatization of β-naphthols and indoles with<i>gem</i>-difluorinated cyclopropanes
Zhiyuan Fu, Jianping Zhu, Songjin Guo, Aijun Lin
Abstract
A palladium-catalyzed allylic alkylation dearomatization of β-naphthols and indoles with gem-difluorinated cyclopropanes has been developed. This reaction provided an efficient route to access 2-fluoroallylic β-naphthalenones and indolenines bearing quaternary carbon centers in good yields with high Z-selectivity via C-C bond activation, C-F bond cleavage and the dearomatization process, benefiting from the wide substrate scope and good functional group tolerance. Moreover, 2-fluoroallylic furanoindoline and pyrroloindolines were achieved in good efficiency via cascade allylic alkylation, dearomatization and cyclization processes in the presence of Et3B.
Topics & Concepts
PalladiumTsuji–Trost reactionCatalysisChemistryAlkylationAllylic rearrangementOrganic chemistryMedicinal chemistryCombinatorial chemistryCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsFluorine in Organic Chemistry