Structural basis for the action of the drug trametinib at KSR-bound MEK
Z.M. Khan, Alexander M. Real, William M. Marsiglia, Arthur Chow, Mary E. Duffy, Jayasudhan R. Yerabolu, Alex P. Scopton, Arvin C. Dar
Topics & Concepts
TrametinibMEK inhibitorMAPK/ERK pathwayAllosteric regulationKRASEffectorScaffold proteinKinaseCell biologyChemistryBiologyBiochemistryMutationSignal transductionEnzymeGeneMelanoma and MAPK PathwaysProtein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling