<i>N</i>-glycosylation of SCAP exacerbates hepatocellular inflammation and lipid accumulation via ACSS2-mediated histone H3K27 acetylation
Xuemei Li, Xiaoqin Tang, Yue Xiang, Zhibo Zhao, Yanping Li, Qiuying Ding, Linkun Zhang, Jingyuan Xu, Lei Zhao, Chen Yao
Abstract
N-glycosylation of SCAP exacerbates inflammation and lipid accumulation in hepatocytes through ACSS2-mediated H3K27ac. Our data suggest that SCAP N-glycosylation plays a key role in regulating histone H3K27 acetylation and targeting SCAP N-glycosylation may be a new strategy for treating nonalcoholic steatohepatitis (NASH).
Topics & Concepts
GlycosylationInflammationSterol regulatory element-binding proteinN-linked glycosylationChemistryHistoneCell biologyAcetylationPhosphorylationHistone H3BiologyBiochemistryTranscription factorGlycoproteinGlycanGeneImmunologyCancer, Lipids, and MetabolismGlycosylation and Glycoproteins ResearchCancer, Hypoxia, and Metabolism