Rh(III)-Catalyzed Oxidative C–H Activation/Domino Annulation of Anilines with 1,3-Diynes: A Rapid Access to Blue-Emitting Tricyclic N,O-Heteroaromatics
Shengyou Qian, Xingwen Pu, Guanjun Chang, Ying Huang, Yudong Yang
Abstract
-Boc-anilines with 1,3-diynes for the construction of tricyclic N,O-heteroaromatics. This reaction features easily available substrates, mild reaction conditions, high regioselectivity, mono/diannulation selectivity, and intra/intermolecular annulation selectivity. Moreover, this synthetic protocol enables the rapid assembly of a library of blue-emitting molecules with high quantum yields, among of which two fluorophores with pure blue-emission in toluene are discovered.
Topics & Concepts
AnnulationChemistryTricyclicCatalysisRegioselectivityDominoSelectivityIntermolecular forceRhodiumCombinatorial chemistryTolueneMoleculeMedicinal chemistryPhotochemistryStereochemistryOrganic chemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsRadical Photochemical Reactions