Renal-specific loss of ferroportin disrupts iron homeostasis and attenuates recovery from acute kidney injury
Abdul Soofi, Vivie Li, Jeffrey A. Beamish, Sham Abdrabh, Mawieh Hamad, Nupur K. Das, Yatrik M. Shah, Gregory R. Dressler
Abstract
Physiological iron homeostasis depends in part on renal resorption and export into the plasma. We show that specific deletion of iron exporters in the proximal tubules sensitizes cells to injury and inhibits recovery. This can promote a chronic kidney disease phenotype. Our paper demonstrates the need for iron balance in the proximal tubules to maintain and promote healthy recovery after acute kidney injury.
Topics & Concepts
FerroportinIron homeostasisHepcidinHomeostasisKidneyAcute kidney injuryMedicineEndocrinologyInternal medicineInflammationMetabolismIron Metabolism and DisordersHemoglobinopathies and Related DisordersErythropoietin and Anemia Treatment