C1 esterase inhibitor and the contact system in COVID‐19
Timothy M. Thomson, Emily Toscano, Ernesto Casís, Rosanna Paciucci
Abstract
Coronavirus disease 2019 (COVID-19) is frequently associated with severe systemic consequences, including vasculitis, a hyperinflammatory state and hypercoagulation. The mechanisms leading to these life-threatening abnormalities are multifactorial. Based on the analysis of publicly available interactomes, we propose that severe acute respiratory syndrome coronavirus-2 infection directly causes a deficiency in C1 esterase inhibitor, a pathogen-specific mechanism that may help explain significant systemic abnormalities in patients with COVID-19.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)ImmunologyMedicineSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Vasculitis2019-20 coronavirus outbreakCoronavirusBetacoronavirusSystemic vasculitisDiseaseVirologyInternal medicineInfectious disease (medical specialty)OutbreakCoagulation, Bradykinin, Polyphosphates, and AngioedemaVitamin K Research StudiesBlood Coagulation and Thrombosis Mechanisms