Rhodium-catalyzed oxidative annulation of 1<i>H</i>-indazoles with alkynes for the synthesis of indazolo[3,2-<i>a</i>]isoquinolines <i>via</i> C–H bond functionalization
Jian Huang, Yang Fu, Zhihong Deng, Wei Chen, Zhibin Song, Yiyuan Peng
Abstract
A Rh(<sc>iii</sc>)-catalyzed oxidative annulation of 1<italic>H</italic>-indazoles with internal alkynes <italic>via</italic> C–C and C–N coupling for the preparation of highly functionalized indazolo[3,2-<italic>a</italic>]isoquinolines is disclosed.
Topics & Concepts
AnnulationSurface modificationCatalysisRhodiumOxidative phosphorylationChemistryCombinatorial chemistryMedicinal chemistryOrganic chemistryBiochemistryPhysical chemistryCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsSynthesis and Catalytic Reactions