Rhodium(III)-Catalyzed Synthesis of Diverse Fluorescent Polycyclic Purinium Salts from 6-Arylpurine Nucleosides and Alkynes
Qi‐Liang Yang, Ying Liu, Yi-Rui Luo, Zhi-Hao Li, Hong-Wei Jia, Ya-Bo Fu, Gui‐Rong Qu, Hai‐Ming Guo
Abstract
Described herein is an efficient strategy for assembling a new library of functionalized polycyclic purinium salts with a wide range of anions through RhIII-catalyzed C–H activation/annulation of 6-arylpurine nucleosides with alkynes under mild reaction conditions. The resulting products displayed tunable photoluminescence covering most of the visible spectrum. Mechanistic insights delineated the rhodium catalyst’s mode of action. A purinoisoquinolinium-coordinated rhodium(I) sandwich complex was well characterized and identified as the key intermediate.
Topics & Concepts
RhodiumChemistryAnnulationCatalysisFluorescenceCombinatorial chemistryBroad spectrumPhotochemistryOrganic chemistryPhysicsQuantum mechanicsCatalytic C–H Functionalization MethodsHIV Research and TreatmentHIV/AIDS drug development and treatment