Regioselective Three-Component Synthesis of Vicinal Diamines via 1,2-Diamination of Styrenes
Jie Cao, Daqi Lv, Fei Yu, Mong‐Feng Chiou, Yajun Li, Hongli Bao
Abstract
The vicinal diamine motif plays a significant role in natural products, drug design, and organic synthesis, and development of synthetic methods for the synthesis of diamines is a long-standing interest. Herein, we report a regioselective intermolecular three-component vicinal diamination of styrenes with acetonitrile and azodicarboxylates. The diamination products can be produced in moderate to excellent yields via the Ritter reaction. Synthetic applications and theoretical studies of this reaction have been conducted.
Topics & Concepts
VicinalRegioselectivityChemistryIntermolecular forceAcetonitrileCombinatorial chemistryComponent (thermodynamics)Organic chemistryDiamineMoleculeCatalysisThermodynamicsPhysicsSynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsOxidative Organic Chemistry Reactions