Gene therapy restores mitochondrial function and protects retinal ganglion cells in optic neuropathy induced by a mito-targeted mutant ND1 gene
Yuan Liu, Jeremy D. Eastwood, Diego Alba, Sindhu Velmurugan, Ning Sun, Vittorio Porciatti, Richard K. Lee, William W. Hauswirth, John Guy, Hong Yu
Topics & Concepts
BiologyGenetic enhancementOptic neuropathyRetinal degenerationMitochondrial DNAOptic nerveMitochondrionMitochondrial diseaseMutantGene deliveryMitochondrial respiratory chainCell biologyMolecular biologyGeneticsGeneNeuroscienceMitochondrial Function and PathologyATP Synthase and ATPases ResearchPhotosynthetic Processes and Mechanisms