Aprocitentan mitigates doxorubicin-induced cardiotoxicity by inhibiting cuproptosis, oxidative stress, and mitochondrial impairments via the activation of sirtuin 7
Yufei Chen, Rui-Qiang Qi, Zhao Lin, Lirong Liang, Jia-Wei Song, Xinyu Zhou, Yihang Chen, Siyuan Wang, Qi Wang, Ying Liu, Ying Dong, Xiaoyan Liu, Jing Li, Jiuchang Zhong
Topics & Concepts
Oxidative stressSirtuinCardiotoxicityDoxorubicinPharmacologySirtuin 1MitochondrionChemistryReactive oxygen speciesOxidative phosphorylationMedicineInternal medicineBiochemistryChemotherapyDownregulation and upregulationAcetylationGeneChemotherapy-induced cardiotoxicity and mitigationMitochondrial Function and PathologySirtuins and Resveratrol in Medicine