Two new cytochalasins from the endophytic fungus <i>Xylaria</i> sp. GDGJ-77B
Zhao-Long Xu, Ben-Chao Li, Li-Li Huang, Liu-Xia Lv, Yan Luo, Weifeng Xu, Rui‐Yun Yang
Abstract
Two new open-chain cytochalasins, xylarchalasins A and B (1 and 2), together with six known analogues (3-8), were isolated from the endophytic fungus Xylaria sp. GDGJ-77B from the Chinese medicinal plant Sophora tonkinensis. Their structures were elucidated on the basis of comprehensive spectroscopic analysis. Compound 2 displayed moderate antibacterial activities against Bacillus subtilis and Escherichia coli with MIC values of 25 and 12.5 μg/mL, respectively.
Topics & Concepts
Plant use of endophytic fungi in defenseFungusBacillus subtilisAntibacterial activityBiologyMicrobiologyBotanyBacteriaGeneticsMicrobial Natural Products and BiosynthesisFungal Biology and ApplicationsMicrobial Metabolism and Applications