The Extracellular Milieu of <i>Toxoplasma</i> 's Lytic Cycle Drives Lab Adaptation, Primarily by Transcriptional Reprogramming
Vincent A. Primo, Yasaman Rezvani, Andrew Farrell, Connor Q. Murphy, Jingjing Lou, Amir Vajdi, Gabor T. Marth, Kourosh Zarringhalam, Marc-Jan Gubbels
Abstract
It has been well established that prolonged in vitro cultivation of Toxoplasma gondii augments progression of the lytic cycle. This lab adaptation results in increased capacities to divide, migrate, and survive outside a host cell, all of which are considered host-independent virulence factors.
Topics & Concepts
BiologyTranscriptomeExtracellularGeneticsTranscription factorLytic cycleGenePhenotypeRegulonCell biologyGene regulatory networkGene expression profilingComputational biologyRegulation of gene expressionVirulenceProteomeEpigenomeAdaptation (eye)Gene expressionChromatinSigma factorExtracellular vesicleMetabolic pathwayVirulence factorMetabolomicsGenomeSystems biologyMYBRNA-SeqToxoplasma gondii Research StudiesCytomegalovirus and herpesvirus researchLegionella and Acanthamoeba research