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Investigation of 3-sulfamoyl coumarins against cancer-related IX and XII isoforms of human carbonic anhydrase as well as cancer cells leads to the discovery of 2-oxo-2H-benzo[h]chromene-3-sulfonamide – A new caspase-activating proapoptotic agent

Dmitry Dar’in, Grigory Kantin, Stanislav Kalinin, Tatiana V. Sharonova, Alexander S. Bunev, Gennady I. Ostapenko, Alessio Nocentini, Vladimir V. Sharoyko, Claudiu T. Supuran, Mikhail Krasavin

2021European Journal of Medicinal Chemistry23 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryCarbonic anhydraseCancer cellEpidermoid carcinomaCoumarinCell cultureBiochemistryCarbonic anhydrase IIGrowth inhibitionIn vitroCell growthCancerStereochemistryEnzymeBiologyGeneticsOrganic chemistryEnzyme function and inhibitionSynthesis and Catalytic ReactionsCholinesterase and Neurodegenerative Diseases
Investigation of 3-sulfamoyl coumarins against cancer-related IX and XII isoforms of human carbonic anhydrase as well as cancer cells leads to the discovery of 2-oxo-2H-benzo[h]chromene-3-sulfonamide – A new caspase-activating proapoptotic agent | Litcius