Investigation of 3-sulfamoyl coumarins against cancer-related IX and XII isoforms of human carbonic anhydrase as well as cancer cells leads to the discovery of 2-oxo-2H-benzo[h]chromene-3-sulfonamide – A new caspase-activating proapoptotic agent
Dmitry Dar’in, Grigory Kantin, Stanislav Kalinin, Tatiana V. Sharonova, Alexander S. Bunev, Gennady I. Ostapenko, Alessio Nocentini, Vladimir V. Sharoyko, Claudiu T. Supuran, Mikhail Krasavin
Topics & Concepts
ChemistryCarbonic anhydraseCancer cellEpidermoid carcinomaCoumarinCell cultureBiochemistryCarbonic anhydrase IIGrowth inhibitionIn vitroCell growthCancerStereochemistryEnzymeBiologyGeneticsOrganic chemistryEnzyme function and inhibitionSynthesis and Catalytic ReactionsCholinesterase and Neurodegenerative Diseases