Preparation of pH-Responsive Vesicular Deferasirox: Evidence from <i>In Silico</i>, <i>In Vitro</i>, and <i>In Vivo</i> Evaluations
Mahmood Barani, Saman Sargazi, Mohammad Reza Hajinezhad, Abbas Rahdar, Fakhara Sabir, Abbas Pardakhty, Farshid Zargari, Md. Khalid Anwer, M. Ali Aboudzadeh
Abstract
< 0.001). Based on the results, the application of pH-responsive DFX-loaded niosomes, as a novel drug delivery platform, may yield promising results in cancer treatment.
Topics & Concepts
In vivoPharmacologyChemistryNiosomeNanocarriersHeLaLipid peroxidationIn vitroApoptosisBiochemistryMedicineOxidative stressDrugVesicleBiologyBiotechnologyMembraneAdvancements in Transdermal Drug DeliveryLipid Membrane Structure and BehaviorErythrocyte Function and Pathophysiology