G protein-coupled receptors: structure- and function-based drug discovery
Dehua Yang, Qingtong Zhou, Viktorija Labroska, Shanshan Qin, Sanaz Darbalaei, Yiran Wu, Elita Yuliantie, Linshan Xie, Houchao Tao, Jianjun Cheng, Qing Liu, Suwen Zhao, Wenqing Shui, Yi Jiang, Ming‐Wei Wang
Abstract
As one of the most successful therapeutic target families, G protein-coupled receptors (GPCRs) have experienced a transformation from random ligand screening to knowledge-driven drug design. We are eye-witnessing tremendous progresses made recently in the understanding of their structure-function relationships that facilitated drug development at an unprecedented pace. This article intends to provide a comprehensive overview of this important field to a broader readership that shares some common interests in drug discovery.
Topics & Concepts
Drug discoveryG protein-coupled receptorPaceComputational biologyFunction (biology)DrugReceptorStructure functionDrug developmentBiologyData scienceBioinformaticsPharmacologyComputer scienceGeneticsGeographyPhysicsGeodesyParticle physicsReceptor Mechanisms and SignalingNeuropeptides and Animal PhysiologyMonoclonal and Polyclonal Antibodies Research