Hyaluronic acid drives mesenchymal stromal cell-derived extracellular matrix assembly by promoting fibronectin fibrillogenesis
Marisa Assunção, Chi Him Kendrick Yiu, Ho-Ying Wan, Dan Wang, Dai Fei Elmer Ker, Rocky S. Tuan, Anna Blocki
Abstract
Hyaluronic acid (HA) is present at sites of ongoing fibronectin fibrillogenesis (fibrillar adhesions) and necessary for efficient fibronectin fibrillogenesis. As a result, fibronectin deposition can be enhanced by exogenous HA.
Topics & Concepts
FibrillogenesisFibronectinHyaluronic acidExtracellular matrixMesenchymal stem cellChemistryBiophysicsFibronectinsCell biologyMatrix (chemical analysis)FibrilCellBiochemistryBiologyAnatomyChromatographyProteoglycans and glycosaminoglycans researchCell Adhesion Molecules ResearchProtease and Inhibitor Mechanisms