Altered Gut Microbiota as a Potential Risk Factor for Coronary Artery Disease in Diabetes: A Two-Sample Bi-Directional Mendelian Randomization Study
Zhaopei Zeng, Junxiong Qiu, Yu Chen, Diefei Liang, Wei Feng, Yuan Fu, Jiarui Zhang, Xiexiao Wei, Xinyi Zhang, Jun Tao, Liling Lin, Junmeng Zheng
Abstract
could pose a risk for DCAD. There is also evidence to suggest that DCAD may, in turn, affect the gut microbiota's makeup. Notably, a surge in serum TMAO levels in individuals with CAD, coinciding with a reduced presence of methanogens, has been identified as a potentially significant factor for future examination.
Topics & Concepts
Mendelian randomizationCoronary artery diseaseGut floraContext (archaeology)Type 2 diabetesGenome-wide association studyDiseaseBiologyGeneticsDiabetes mellitusBioinformaticsInternal medicineMedicineSingle-nucleotide polymorphismImmunologyEndocrinologyGenetic variantsGenePaleontologyGenotypeGut microbiota and healthFood Security and Health in Diverse PopulationsHelicobacter pylori-related gastroenterology studies