Temporal pressure enhanced topical drug delivery through micropore formation
Daniel Chin Shiuan Lio, Rui Ning Chia, Milton Sheng Yi Kwek, Christian Wiraja, Leigh Madden, Hao Chang, S. Mohideen Abdul Khadir, Xiaomeng Wang, David L. Becker, Chenjie Xu
Abstract
) on the epidermal layer through a temporal pressure treatment results in the elevated expression of gap junctions, and reduced expression of occludin tight junctions. A 1 min treatment of 0.28-MPa allows nanoparticles (up to 500 nm) and macromolecules (up to 20 kDa) to reach a depth of 430-μm into the dermal layer. Using, as an example, the delivery of insulin through topical application after the pressure treatment yields up to 80% drop in blood glucose in diabetic mice.
Topics & Concepts
Drug deliveryDrugMicroporous materialMedicineComputer scienceNanotechnologyPharmacologyChemistryMaterials scienceOrganic chemistryAdvancements in Transdermal Drug DeliveryDermatology and Skin DiseasesAdvanced Drug Delivery Systems