An N-capping asparagine–lysine–proline (NKP) motif contributes to a hybrid flexible/stable multifunctional peptide scaffold
Marlon H. Cardoso, Lai Yue Chan, Elizabete de Souza Cândido, Danieli Fernanda Buccini, Samilla B. Rezende, Marcelo D. T. Torres, Karen G. N. Oshiro, Ítala C. Silva, Sónia Gonçalves, Timothy K. Lu, Nuno C. Santos, César de la Fuente‐Núñez, David J. Craik, Octávio Luiz Franco
Abstract
, reduced lipopolysaccharide-induced macrophages stress, and stimulated fibroblast migration for wound healing. This study extends our understanding of an N-capping NKP motif to engineering hybrid multifunctional peptide drug candidates with potent anti-infective and immunomodulatory properties.
Topics & Concepts
AsparagineLysineProlineChemistryPeptideScaffoldStructural motifMotif (music)Cyclic peptideBiochemistryCombinatorial chemistryStereochemistryAmino acidMedicineBiomedical engineeringPhysicsAcousticsAntimicrobial Peptides and ActivitiesChemical Synthesis and AnalysisNeuropeptides and Animal Physiology