Loss of AKR1B10 promotes colorectal cancer cells proliferation and migration via regulating FGF1-dependent pathway
Yizhou Yao, Xuchao Wang, Diyuan Zhou, Hao Li, Huan Qian, Jiawen Zhang, Lin‐Hua Jiang, Bin Wang, Qi Lin, Xinguo Zhu
Abstract
, and increased the expression of FGF1. Finally, AKR1B10 inhibited FGF1, and suppressed the proliferation and migration ability of CRC cells in an FGF1-dependent manner. In conclusion, AKR1B10 acts as a tumor suppressor in CRC by inactivating FGF1, and is a novel target for combination therapy of CRC.
Topics & Concepts
Colorectal cancerFGF1Cancer researchCell biologyCancerBiologyMedicineInternal medicineFibroblast growth factorReceptorFibroblast growth factor receptorAldose Reductase and TaurinePrenatal Substance Exposure Effects