Radical Acylalkylation of 1,3-Enynes To Access Allenic Ketones via <i>N</i>-Heterocyclic Carbene Organocatalysis
Yanqing Liu, Qing‐Zhu Li, Xin‐Xin Kou, Rong Zeng, Ting Qi, Xiang Zhang, Cheng Peng, Bo Han, Jun‐Long Li
Abstract
-heterocyclic carbene organocatalytic 1,4-difunctionalization of 1,3-enynes was developed. This organocatalytic strategy was suitable for a broad spectrum of substrates to efficiently synthesize allenic ketones bearing diverse substituents. Preliminary mechanistic studies suggest a radical reaction pathway for this organocatalytic acylalkylation process.
Topics & Concepts
CarbeneOrganocatalysisChemistryCatalysisOrganic chemistryCombinatorial chemistryStereochemistryEnantioselective synthesisN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions