HOXB13 promotes gastric cancer cell migration and invasion via IGF-1R upregulation and subsequent activation of PI3K/AKT/mTOR signaling pathway
Cheng-Ming Guo, Hongjin Chu, Zhaohua Gong, Bo Zhang, Chen Li, Jian Chen, Liuye Huang
Topics & Concepts
PI3K/AKT/mTOR pathwayProtein kinase BBiologyCell growthCancer researchDownregulation and upregulationSignal transductionMolecular biologyChemistryCell biologyGeneGeneticsCancer-related Molecular PathwaysTGF-β signaling in diseasesGrowth Hormone and Insulin-like Growth Factors