Electrochemical synthesis of functionalized <i>gem</i>-difluoroalkenes with diverse alkyl sources <i>via</i> a defluorinative alkylation process
Haoxiang Zhang, Mengze Liang, Xiǎo Zhang, Mengke He, Chao Yang, Lin Guo, Wujiong Xia
Abstract
An electrochemical defluorinative alkylation of α-trifluoromethyl alkenes is described. This reaction enables the preparation of functionalized gem -difluoroalkenes with diverse alkyl sources including organohalides, NHP esters, and Katritzky salts.
Topics & Concepts
ChemistryAlkylationAlkylCombinatorial chemistryElectrochemistryProcess (computing)Organic chemistryCatalysisElectrodePhysical chemistryOperating systemComputer scienceFluorine in Organic ChemistryRadical Photochemical ReactionsCatalytic C–H Functionalization Methods