Is (R)-ketamine a potential therapeutic agent for treatment-resistant depression with less detrimental side effects? A review of molecular mechanisms underlying ketamine and its enantiomers
Ellen Scotton, Bárbara Antqueviezc, Mailton Vasconcelos, Giovana Dalpiaz, Luíza Paul Géa, Jéferson Ferraz Goularte, Rafael Colombo, Adriane Ribeiro Rosa
Topics & Concepts
KetamineNMDA receptorAntidepressantPharmacologyNeuroplasticityPI3K/AKT/mTOR pathwaySynaptic plasticityNeurotrophic factorsNeurosciencePsychologyMedicineSignal transductionChemistryHippocampusReceptorInternal medicineBiochemistryTreatment of Major DepressionTryptophan and brain disordersNeuroscience and Neuropharmacology Research