Enterovirus 2A <sup>pro</sup> Cleavage of the YTHDF m <sup>6</sup> A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling
Jonathan P. Kastan, Martine Tremblay, Michael C. Brown, Joseph D. Trimarco, Elena Y. Dobrikova, Mikhail I. Dobrikov, Matthias Gromeier
Abstract
A-modified mRNA, yet their biological functions remain obscure. We discovered that polio/enteroviruses elicit very early proteolysis of YTHDF1 to 3 in infected cells. Our research demonstrates that YTHDF3 acts as a positive regulator of antiviral JAK/STAT signaling in response to positive single-strand RNA virus infection, enabling type I interferon (IFN)-mediated gene regulatory programs to unfurl in infected cells. Our observation of viral degradation of the YTHDF proteins demonstrates that they are key response modifiers in the innate antiviral immune response.
Topics & Concepts
MediatorVirologyInterferonstatBiologySignal transductionChemistryCell biologySTAT3RNA modifications and cancerCancer-related molecular mechanisms researchRNA Research and Splicing