Dual Targeting of VEGFR2 and C-Met Kinases via the Design and Synthesis of Substituted 3-(Triazolo-thiadiazin-3-yl)indolin-2-one Derivatives as Angiogenesis Inhibitors
Samy Mohamady, Mahmoud Galal, Wagdy M. Eldehna, David C. Gutierrez, Hany S. Ibrahim, Mohamed M. Elmazar, Hamed I. Ali
Abstract
to investigate its mode of interaction within the binding site of both c-Met and VEGFR2 kinases.
Topics & Concepts
KinaseAngiogenesisChemistryVEGF receptorsDual (grammatical number)Cancer researchBiochemistryMedicineArtLiteratureCancer Mechanisms and TherapyCytokine Signaling Pathways and InteractionsAngiogenesis and VEGF in Cancer