Reabsorption of bile acids regulated by FXR-OATP1A2 is the main factor for the formation of cholesterol gallstone
Jingli Cai, Zhaowen Wang, Guiming Chen, Dapeng Li, Jun Liu, Hai Hu, Jian Qin
Abstract
For the first time, our results indicate that the axis of farnesoid X receptor-organic anion transporter polypeptide 1A2 that physiologically regulates the reabsorption of bile acids might play an important role in the regulation of the composition of bile acids and make contribution to the development of cholelithiasis.
Topics & Concepts
Farnesoid X receptorReabsorptionChemistryTransporterCholesterolOrganic anion transporter 1Bile acidInternal medicineBiochemistryEndocrinologyNuclear receptorBiologyTranscription factorMedicineGeneSodiumOrganic chemistryDrug Transport and Resistance MechanismsPediatric Hepatobiliary Diseases and TreatmentsGallbladder and Bile Duct Disorders